Molecular Epidemiology: Applications in Cancer and Other Human Diseases

Molecular Epidemiology: Applications in Cancer and Other Human Diseases Review

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Molecular Epidemiology: Applications in Cancer and Other Human Diseases Feature

This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring:

• design considerations in molecular epidemiology, including:

• case-only
• family-based
• approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics
• incorporation of biomarkers in clinical trials

• measurement issues in molecular epidemiology, including

• DNA biosampling methods
• principles for high-quality genotyping
• haplotypes
• biomarkers of exposure and effect
• exposure assessment

• methods of statistical inference used in molecular epidemiology, including

• gene-gene and gene-environment interaction analysis
• novel high-dimensional analysis approaches
• pathway-based analysis methods
• haplotype methods, dealing with race and ethnicity
• risk models
• a discussion of reporting and interpreting results

• A specific discussion and synopsis of these methods provides concrete examples drawn from primary research in cancer

Covering design considerations, measurement issues, and methods of statistical inference, and filled with scientific tables, equations, and pictures, Molecular Epidemiology: Applications in Cancer and Other Human Diseases presents a solid, single-source foundation for conducting and interpreting molecular epidemiological studies.

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Post-Transcriptional Gene Regulation (Methods in Molecular Biology)

Post-Transcriptional Gene Regulation (Methods in Molecular Biology) Review

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Post-Transcriptional Gene Regulation (Methods in Molecular Biology) Feature

This volume strives to present current technical approaches to most aspects of post-transcriptional control and provide the reader with a useful and versatile laboratory bench resource. With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their laboratories.

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Molecular Biology of the SARS-Coronavirus

Molecular Biology of the SARS-Coronavirus Review

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Molecular Biology of the SARS-Coronavirus Feature

The SARS outbreak in 2002 caused unprecedented devastation and exhibited unusually high rates of morbidity and mortality. For the SARS coronavirus, the transmission vehicle was man. What added to the spread was man’s convenient, rapid and affordable ways of travel that caused the virus to spread globally in a short span of time. The SARS coronavirus jumped the species barrier, similar to many recent zoonotic diseases – avian flu, swine flu, Nipah and encephalitis virus. It is extremely important for us to understand the enemy before it strikes again in order to be able to combat such outbreaks as and when they occur. Molecular mechanisms that the virus exploits within its host and that result in infection and pathogenesis are the key to being able to block its transmission cycle. In this book, leading scientists from around the globe have discussed molecular aspects of viral entry, replication, viral gene expression, pathogenesis and host immune response against the SARS coronavirus.

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Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine)

Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine) Review

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Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine) Feature

This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The contributors are world-renown leaders in the field. They describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. They discuss HLA typing, PCR-SSP typing, and HLA antigens. This volume is an invaluable source for biochemists, molecular biologists, and clinicians.

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Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine)

Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine) Review

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Bone Marrow and Stem Cell Transplantation (Methods in Molecular Medicine) Feature

This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The contributors are world-renown leaders in the field. They describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. They discuss HLA typing, PCR-SSP typing, and HLA antigens. This volume is an invaluable source for biochemists, molecular biologists, and clinicians.

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DNA Methylation: Methods and Protocols (Methods in Molecular Biology)

DNA Methylation: Methods and Protocols (Methods in Molecular Biology) Review

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DNA Methylation: Methods and Protocols (Methods in Molecular Biology) Feature

Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.

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